Composizione

BIOMETABOLIC^® è composto da materie prime Italiane e dell'Unione europea

INGREDIENTI: Carbonato di calcio(*); Alga Chlorella polvere (Chlorella vulgaris Beijerinck, thallus (singulae cellulae)); maltodestrina da mais; Ferro liposomiale (amido di mais, ferro pirofosfato, lecitina da girasole); agente di carica: idrossipropilmetilcellulosa; antiagglomerante: sali di magnesio degli acidi grassi; Coenzima Q10; Solfato di zinco; Vitamina D (Colecalciferolo); Vitamina A (retinil-acetato-RE); Acido folico (Acido pteroil-monoglutammico); Ioduro di potassio; Vitamina B12 (Cianocobalamina). (*) Origine UE

Modalità di assunzione

Si consiglia di assumere 2 compresse al giorno per una durata di 30 giorni. Le compresse sono facilmente divisibili, vanno ingerite con mezzo bicchiere d’acqua, preferibilmente entrambe a metà mattinata.

AVVERTENZE: Si consiglia di non superare la dose giornaliera raccomandata e conservare in luogo fresco e asciutto, lontano da fonti di calore e dalla luce. Gli integratori non vanno intesi come sostituti di una dieta varia ed equilibrata ed uno stile di vita sano. Il prodotto è consigliato ad un pubblico adulto.

CALCIO

1. Lidia Wadolowska et al., “Dairy-Related Dietary Patterns, Dietary Calcium, Body Weight and Composition: A Study of Obesity in Polish Mothers and Daughters, the MODAF Project”. Nutrients, 2018.
2. J. Jürimäe et al., “Association between Dietary Calcium Intake and Adiposity in Male Adolescents” Nutrients, 2019.
3. K. W. Lee e W. Cho, “The Consumption of Dairy Products Is Associated with Reduced Risks of Obesity and Metabolic Syndrome in Korean Women but not in Men”, Nutrients. 2017.
4. A. Nappo, “Dietary calcium intake and adiposity in children and adolescents: Crosssectional and longitudinal results from IDEFICS/I.Family cohort” Nutrition, Metabolism & Cardiovascular Diseases. 2019.
5. D. K. Tidwell, M. W. Valliant, “Higher amounts of body fat are associated with inadequate intakes of calcium and vitamin D in African American women”, Nutrition Research. 2011.
6. M. Samadi et al., “Dietary calcium intake and risk of obesity in school girls aged 8-10 years”, Journal of Research in Medical Sciences. 2012
7. J. C. Burbano et al., “Relationship between dietary calcium intake and adiposity in female adolescents”, Endocrinología y Nutrición. 2016.
8. U. Yamborisut et al., “Calcium Intake in Relation to Body Mass Index and Fatness in Thai School-Aged Children”, Open Journal of Pediatrics. 2015.
9. A. Dougkas et al., “Associations between dairy consumption and body weight: a review of the evidence and underlying mechanisms”, Nutrition Research Reviews. 2011.

FERRO

1. G. Kaner et al., “Is iron deficiency related with increased body weight? A cross-sectional study”, Progress in Nutrition. 2016.
2. E. E. Sypes et al., “Higher Body Mass Index Is Associated with Iron Deficiency in Children 1 to 3 Years of Age”, The Journal of Pediatrics. 2019.
3. Mr Sharif et al.,” Comparative Evaluation of Iron Deficiency among Obese and Nonobese Children”, Iranian Journal of Pediatric Hematology and Oncology. 2014.
4. M. H. Al-Zahrani et al., “Association between the Iron Status and Body Mass Index of Female Students in the Faculty of Science of King Abdulaziz University”, Journal Of Biochemical Technology. 2019.
5. Álvaro GonzÁlez-Domínguez et al., “Iron Metabolism in Obesity and Metabolic Syndrome”, International Journal of Molecular Sciences. 2020.

IODIO

1. A. Lecube et al., “Iodine deficiency is higher in morbid obesity in comparison with late after bariatric surgery and non-obese women”, Obesity Surgery. 2015.
2. G. Farhat et al., “Inadequacies of micronutrient intake in normalweight and overweight young adults aged 18e25years: a cross-sectional study”, Public Health. 2019.
3. S. Saytin Cruz-Mejía et al., “Body mass index is associated with interleukin-
4. adiponectin, oxidative stress and ioduria levels in healthy adults”, Nutricion Hospitalaria. 2018.
5. J. Costa Leite et al., “Iodine Status and Iodised Salt Consumption in Portuguese School- Aged Children: The Iogeneration Study”, Nutrients. 2017.

ZINCO

1. L. M. Hafez et al., “Studying a possible relationship among serum leptin, serum zinc and BMI in children”, Alexandria Journal of Pediatrics. 2018.
2. M. Zohal et al., “Association between selected trace elements and body mass index and waist circumference: A cross sectional study”, Diabetology & Metabolic Syndrome. 2019.
3. M.M. Abdel Gawad et al., “Serum zinc level and its relation to insulin resistance and lipid profile in childhood and adolescent obesity”, Alexandria Faculty of Medicine. 2017.
4. J. Suliburska et al., “The evaluation of selected serum mineral concentrations and their association with insulin resistance in obese adolescents”, European Review for Medical and Pharmacological Sciences. 2013.
5. L. Payahoo et al., “Effects of Zinc Supplementation on the Anthropometric Measurements, Lipid Profiles and Fasting Blood Glucose in the Healthy Obese Adults”, Advanced Pharmaceutical Bulletin. 2013.
6. R. Kelishadi et al., “Effect of zinc supplementation on markers of insulin resistance, oxidative stress, and inflammation among prepubescent children with metabolic syndrome”, Metabolic Syndrome and Related Disorders. 2010.
7. Doaa S.E. Zaky et al., “Zinc level and obesity”, The Egyptian Journal of Internal Medicine. 2013.
8. Y. Fan et al., “Relationship between Selected Serum Metallic Elements and Obesity in Children and Adolescent in the U.S”, Nutrients. 2017.

VITAMINA A

1. C. Bento et al., “Vitamin A deficiency is associated with body mass index and body adiposity in women with recommended intake of vitamin A”, Nutricion hospitalaria. 2018.
2. X. Wei et al., “Serum vitamin A status is associated with obesity and the metabolic syndrome among school-age children in Chongqing, China”, Asia Pacific Journal of Clinical Nutrition. 2016.
3. Małgorzata Godala et al., “The risk of plasma vitamin A, C, E and D deficiency in patients with metabolic syndrome: A case-control study”, 2017.
4. O. García et al., “Zinc, vitamin A, and vitamin C status are associated with leptin concentrations and obesity in Mexican women: results from a cross-sectional study”, Nutrition & Metabolism. 2012.
5. MA Zulet et al., “Vitamin A intake is inversely related with adiposity in healthy young adults”, The Journal of Nutritional Science and Vitaminology. 2008.

VITAMINA B12

1. D. Baltaci et al., “Association of vitamin B
2. with obesity, overweight, insulin resistance and metabolic syndrome, and body fat composition; primary care-based study”, Medicinski Glasnik. 2013.
3. D Baltaci et al., “Evaluation of serum Vitamin B
4. level and related nutritional status among apparently healthy obese female individuals”. The Nigerian Journal of Clinical Practice. 2017.
5. S. Ozer et al., “Negative correlation among vitamin B
6. levels, obesity severity and metabolic syndrome in obese children: A case control study”, Journal Of Pakistan Medical Association. 2017.
7. Y. Sun et al., “Inverse Association Between Serum Vitamin B
8. Concentration and Obesity Among Adults in the United States”, Frontiers in Endocrinology. 2019.
9. R. Goyal et al., “To study the vitamin b
10. status in morbidly obese patients”, International Journal of food and Nutritional Sciences. 2013.
11. M Ho et al., “Vitamin B
12. in obese adolescents with clinical features of insulin resistance”, Nutrients. 2014.
13. M. A. Samak et al., “Relationship of Vitamin B
14. Deficiency with Overweight in Male Jordanian Youth”, Science Alert. 2008

VITAMINA D

1. L. Q. Tian et al., “The Association of Serum Vitamin D Deficiency and Metabolic Risk Factors in Chinese Adults with Prediabetes: A Cross-Sectional Study”, Journal of Nutritional Science and Vitaminology. 2019.
2. R. Rafiq et al., “Associations of different body fat deposits with serum 25-hydroxyvitamin D concentrations”, Clinical Nutrition. 2019.
3. J. L. Plesner et al., “Obesity is associated with vitamin D deficiency in Danish children and adolescents”, Journal of Pediatric Endocrinology and Metabolism. 2018.
4. M. Censani et al., “Vitamin D Deficiency Associated With Markers of Cardiovascular Disease in Children With Obesity”, Global Pediatric Health. 2018.
5. M G Nikolova et al., “Correlations of serum vitamin d with metabolic parameters in adult outpatients with different degrees of overweight / obesity coming from an urban community”, Acta Endocrinologica. 2018.
6. E. Z. Azzam et al., “DObesity: Relationship between vitamin D deficiency, obesity and sclerostin as a novel biomarker of bone metabolism”, Journal of Clinical & Translational Endocrinology. 2019.
7. M. Kumaratne et al., “Vitamin D Deficiency and Association With Body Mass Index and Lipid Levels in Hispanic American Adolescents”, Global Pediatric Health. 2017.
8. Sarah M. Cork et al.,” The Relationship Between Vitamin D Status and Body Mass Index in a Racially Diverse Urban Population of Male and Female Pre- and Early Adolescents”, Georgia State University 2017.
9. T. DurÁ-Travé et al., “Assessment of vitamin D status and parathyroid hormone during a combined intervention for the treatment of childhood obesity”, Nutrition & Diabetes. 2019.
10. S. Delle Monache et al., “Body mass index represents a good predictor of vitamin D status in women independently from age”, Clinical Nutrition. 2019.
11. L. Rocha et al., “Body composition and metabolic profile in adults with vitamin D deficiency”, Revista de Nutrição. 2017.

FOLATI

1. S. Köse et al., “Obesity is associated with folate metabolism”, International Journal for Vitamin and Nutrition Research. 2020.

COENZIMA Q10

1. Z. Xu et al., “Coenzyme Q10 Improves Lipid Metabolism and Ameliorates Obesity by Regulating CaMKII-Mediated PDE4 Inhibition”, Scientific Reports - Nature. 2017.
2. D. Casagrande et al., “Mechanisms of action and effects of the administration of Coenzyme Q10 on metabolic syndrome”, Journal of Nutrition & Intermediary Metabolism. 2018.
3. Md Ashraful Alam et al., “Mitochondrial dysfunction in obesity: potential benefit and mechanism of Co-enzyme Q10 supplementation in metabolic syndrome”, Journal of Diabetes & Metabolic Disorders. 2014.

ALGA CHLORELLA

1. T. Mizoguchi et al., “Nutrigenomic Studies of Effects of Chlorella on Subjects With High- Risk Factors for Lifestyle-Related Disease”, Journal of Medicinal Food. 2008.
2. J.W. Chon et al., “Chlorella methanol extract reduces lipid accumulation in and increases the number of apoptotic 3T3-L1 cells”, Annals of the New York Academy of Sciences. 2009.
3. M. Ebrahimi-Mameghani et al., “The Effect of Chlorella vulgaris Supplementation on Liver Enzymes, Serum Glucose and Lipid Profile in Patients with Non-Alcoholic Fatty Liver Disease”. 2014.